March Madness Betting: Biggest Line Moves Opening Round 2025 NCAA Tournament

The Connecticut Huskies enter the 2025 NCAA Tournament as the 2-time defending men's college ... [+] basketball champions. March Madness is the biggest betting event of the year. (Photo by Carmen Mandato/Getty Images)
Getty Images
The 2025 men’s NCAA Tournament tipped off Tuesday and Wednesday with the First Four play-in games. March Madness really begins with the college basketball field of 64 playing 32 games on Thurday and Friday. How to bet on March Madness and the biggest watch and wager event of the year is most popular with fans building basketball brackets and entering contest pools driving additional engagement, excitement and interest in the event.
But betting on the games and making futures bets on teams to win the East and West region or South and Midwest region offers more ways to win beyond betting on a national champion.
March Madness Odds, Mathups And First Round Line Moves
FanDuel Sportsbook provides college basketball betting odds for the most watched and wagered college basketball games. Odds and futures refresh periodically and are subject to change, including on props and live betting. Bet types, odds and betting terms along with upcoming games and odds will be updated as provided by FanDuel and leading online sportsbooks. Betting favorites (-) listed.
When the NCAA Committee released the field of 68 on the CBS Sunday Selection Show, the top online sportsbooks released the matchups and odds withing an hour. Some of the biggest and best sportsbooks in Las Vegas often set the market like Circa, Southpoint and SuperBook. Those off The Strip properties have regular customers that bet heavier into the opening numbers. So do the Wynn, Caesars or BetMGM sportsbooks that dominate the Las Vegas Strip properties.